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When home treatment is not enough If injection site reactions are severe, persistent, or worsening despite the measures above, medical intervention may include prescription-strength topical steroids (triamcinolone 0.1 percent), oral corticosteroid courses for widespread reactions, or evaluation for potential allergy to a specific component of the formulation
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α 2 agonist treatment (five studies with clonidine, one with lofexidine) was more effective than placebo and more likely to result in the completion of treatment, withdrawal signs and symptoms occurred and resolved earlier than methadone, and treatment duration was shorter
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