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This mutation, at locus 4p16.3, in the IT15 gene, was discovered to be an expansion of a CAG repeat in the huntingtin (HTT) gene resulting in an expanded polyglutamine tract (The Huntington’s Disease Collaborative Research Group, 1993)

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2 Gender and Hormones Women are more likely to struggle with insomnia than men, and changes in levels of female hormones (estrogen and progesterone) that occur with menstrual cycling, pregnancy, and the menopausal transition are thought to play a role