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Patients with moderate TBI (GCS 9–13) may experience initial lethargy or stupor, while those with severe TBI (GCS 3–8) may be in a comatose state and unable to open their eyes or respond to commands

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The molecular mechanism(s) by which calcineurin regulates the function of Gdt1 and Vcx1 remain unknown, as neither protein undergoes changes in expression or mobility on SDS-PAGE upon activation/inhibition of calcineurin